We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Correspondence |

Calciphylaxis Associated With Chronic Inflammatory Conditions, Immunosuppression Therapy, and Normal Renal Function: A Report of 2 Cases

Allison M. Swanson, MD; Seemal R. Desai, MD; Jeremy D. Jackson, MD; Aleodor A. Andea, MD; Lauren C. Hughey, MD
Arch Dermatol. 2009;145(6):723-725. doi:10.1001/archdermatol.2009.103.
Text Size: A A A
Published online


Calciphylaxis is a syndrome of vascular calcification and skin necrosis commonly associated with chronic renal failure. We present 2 cases of calciphylaxis in patients with chronic inflammatory conditions and immunosuppression but normal renal function.

Gipstein  RMCoburn  JWAdams  DA  et al.  Calciphylaxis in man: a syndrome of tissue necrosis and vascular calcification in 11 patients with chronic renal failure. Arch Intern Med 1976;136 (11) 1273- 1280
PubMed Link to Article[[XSLOpenURL/10.1001/archinte.1976.03630110043012]]
Goli  AKGoli  SAShah  LSByrd  RP  JrRoy  TM Calciphylaxis: a rare association with alcoholic cirrhosis: are deficiencies in protein C and S the cause? South Med J 2005;98 (7) 736- 739
PubMed Link to Article[[XSLOpenURL/10.1097/01.SMJ.0000154316.22472.97]]
Korkmaz  CDundar  EZubaroglu  I Calciphylaxis in a patient with rheumatoid arthritis without renal failure and hyperparathyroidism: the possible role of long-term steroid use and protein S deficiency. Clin Rheumatol 2002;21 (1) 66- 69
PubMed Link to Article[[XSLOpenURL/10.1007/s100670200016]]
Arseculeratne  GEvans  ATMorley  SM Calciphylaxis: a topical overview. J Eur Acad Dermatol Venereol 2006;20 (5) 493- 502
PubMed Link to Article[[XSLOpenURL/10.1111/jdv.2006.20.issue-5]]
Weenig  RH Pathogenesis of calciphylaxis: Hans Selye to nuclear factor kappa-B. J Am Acad Dermatol 2008;58 (3) 458- 471
PubMed Link to Article[[XSLOpenURL/10.1016/j.jaad.2007.12.006]]
Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Figure 1.

Clinical (A) and histopathologic (B) images from case 1. A, Violaceous plaque containing necrotic, punched-out ulcerations on the right lower extremity. B, Medium-sized deep-dermal vessel exhibiting medial calcification accompanied by luminal narrowing (hematoxylin-eosin, original magnification ×200).

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Clinical (A) and histopathologic (B) images from case 2. A, Necrotic ulcer on the lower leg. B, Small artery within the subcutis with circumferential calcification of the media (arrow) and intimal fibrosis (hematoxylin-eosin, original magnification ×100).

Graphic Jump Location




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

9 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles