Nigrospora is rarely an opportunistic pathogen in humans. To our knowledge, there have been 4 reports on Nigrospora-induced human eye and skin infections in the literature.1- 3 However, none of these cases included definite clinicopathologic evidence or species identification. Herein, we report the first case to our knowledge of Nigrospora sphaerica–induced onychomycosis in humans.
Patient's toe before and after treatment. A, White discoloration on the whole dorsal surface of the nail plate of the right first toenail. B, After treatment, clinical cure of nail plate.
Histomycologic image of nail clippings showing purple spores and hyphae (periodic acid–Schiff stain, original magnification ×1000).
Microculture on Sabouraud dextrose agar at 27°C after 1 week showing spherical or oblate black and single-celled conidia developing from conidiogenous cells (original magnification ×400).
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