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Correspondence |

Sweet Syndrome Associated With New-Onset Systemic Lupus Erythematosus in a 25-Year-Old Man

Neil F. Fernandes, MD; Leslie Castelo-Soccio, MD, PhD; Ellen J. Kim, MD; Victoria P. Werth, MD
Arch Dermatol. 2009;145(5):608-609. doi:10.1001/archdermatol.2009.82.
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Sweet syndrome (SS) is a reactive neutrophilic process characterized by tender, erythematous papules and plaques, fever, and leukocytosis and is associated with underlying infections, inflammatory diseases, and malignant neoplasms. To our knowledge, only 2 cases of SS associated with new-onset systemic lupus erythematosus (SLE) have been reported—one in an adult woman and the other in a 14-year-old girl.1,2 We report the first case in an adult man.

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Figure 1.

Photograph of 1 tender erythematous plaque with a central pustule located on the anterior thigh.

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Figure 2.

Histopathologic images from our case. A, Low-power hematoxylin-eosin–stained specimen of a skin lesion showing peripheral epidermal blister formation and a dense dermal infiltrate with leukocytoclasia but no evidence of vasculitis (original magnification ×40). B, High-power hematoxylin-eosin–stained specimen reveals an infiltrate composed largely of neutrophils (original magnification ×400). Findings under Gram, Grocott, and acid-fast bacilli stains were all negative.

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