Correspondence |

Remote Hemorrhagic Bullae Occurring in a Patient Treated With Subcutaneous Heparin

Urvi Pajvani Gonzales, MD; Glynis A. Scott, MD; Alice J. Briones, MD; Alice P. Pentland, MD
Arch Dermatol. 2009;145(5):604-605. doi:10.1001/archdermatol.2009.70.
Text Size: A A A
Published online


Hemorrhagic bullae often have underlying infectious causes. However, recent reports have suggested that they may also occur at sites distant from subcutaneous heparin injections,1,2 which have been linked to a variety of other skin manifestations including urticaria, erythema, calcinosis cutis, skin necrosis often secondary to vasculitis, and heparin-induced thrombocytopenia.3,4

Figures in this Article

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Figure 1.

Figure 1. Clinical (A) and close-up (B) views of multiple hemorrhagic vesicles and bullae occurring on the anterolateral surface of the lower extremity.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Figure 2. Skin biopsy specimens reveal characteristic features of bullous hemorrhagic dermatosis. A, Subcorneal collection of red blood cells within an intact vesicle (hematoxylin-eosin, original magnification ×10). B, Neutrophils and eosinophils within the dermis without evidence of vasculitis (hematoxylin-eosin, original magnification ×40).

Graphic Jump Location




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles