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Correspondence |

Localized Palmar Vancomycin-Induced Linear IgA Bullous Dermatosis Occurring at Supratherapeutic Levels

Sarah N. Walsh, MD; Katherine Kerchner, MD; Omar P. Sangüeza, MD
Arch Dermatol. 2009;145(5):603-604. doi:10.1001/archdermatol.2009.68.
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Nousari  HCKimyai-Asadi  ACaeiro  JPAnhalt  GJ Clinical, dermographic, and immunohistologic features of vancomycin-induced linear IgA bullous disease of the skin: report of 2 cases and review of the literature. Medicine (Baltimore) 1999;78 (1) 1- 8
PubMed Link to Article[[XSLOpenURL/10.1097/00005792-199901000-00001]]
Neughebauer  BINegron  GPelton  SPlunkett  RWBeutner  EHMagnussen  R Bullous skin disease: an unusual allergic reaction to vancomycin. Am J Med Sci 2002;323 (5) 273- 278
PubMed Link to Article[[XSLOpenURL/10.1097/00000441-200205000-00009]]
Navi  DMichael  DJFazel  N Drug-induced linear IgA bullous dermatosis. Dermatol Online J 2006;12 (5) 12
PubMed
Armstrong  AWFazeli  AYeh  SWMackool  BTLui  V Vancomycin-induced linear IgG disease manifesting as bullous erythema multiforme. J Cutan Pathol 2004;31 (5) 393- 397
PubMed Link to Article[[XSLOpenURL/10.1111/cup.2004.31.issue-5]]
Dellavalle  RPBurch  JMTayal  SGolitz  LEFitzpatrick  JEWalsh  P Vancomycin-associated linear IgA bullous dermatosis mimicking toxic epidermal necrolysis. J Am Acad Dermatol 2003;48 (5) (suppl)S56- S57
PubMed Link to Article[[XSLOpenURL/10.1067/mjd.2003.116]]
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Figure 1.

Figure 1. Initial appearance of the lesions as tense bullae on an erythematous base involving the palmar surfaces bilaterally.

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Figure 2.

Figure 2. Direct immunofluorescence shows strong linear staining of the basement membrane along the dermoepidermal junction with IgA (original magnification ×20).

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