Fifty-one patients with LET were treated at the outpatient unit for connective tissue diseases at the dermatologic clinic at Ruhr University Bochum, Bochum, Germany. The observation period was 2 years (January 1, 2006, through December 31, 2007). To be eligible for this retrospective study, patients were required to meet the clinical and histopathologic criteria for LET published by Kuhn et al.5 Only patients with multifocal LET, defined as at least 3 lesions of 2 cm or larger in greatest diameter, were included. Exclusion criteria were as follows: pregnancy or lactation, concomitant systemic corticosteroid therapy, any concomitant internal immunomodulating or immunosuppressive therapy, and any concomitant topical therapy (eg, with topical corticosteroids or topical calcineurin inhibitors). Additional topical therapy was restricted to the use of emollients and sunscreens. As a standard workup in all patients with CLE, a detailed medical history (including current medications, comorbidities, and smoking status) and physical examination, urinalysis, chest radiography, echocardiography, and ultrasonography of the abdomen were performed in each patient. Serologic analysis included complete blood cell count, antinuclear antibodies, screening for extractable nuclear antibodies (including anti-Ro and anti-La antibodies, anti-Smith antibodies, anti-U1-ribonucleoprotein antibodies, antihistone antibodies, antitopoisomerase-1 antibodies, and anti-Jo-1 antibodies), anti–double-stranded deoxyribonucleic antibodies, rheumatoid factor, circulating immune complexes, complement components (C3 and C4), C-reactive protein, immunoglobulin levels (IgA, IgM, and IgG), and routine blood chemistry testing. Appropriate institutional review board approval was obtained for review of patient medical records.