March 2009, Vol 145, No. 3 >

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Correspondence | March 2009

Stage III Melanoma Treated With Chemotherapy After Surgery During the Second Trimester of Pregnancy

Isao Ishida, MD, PhD; Yuji Yamaguchi, MD, PhD; Atsushi Tanemura, MD, PhD; Ko Hosokawa, MD, PhD; Satoshi Itami, MD, PhD; Akimichi Morita, MD, PhD; Ichiro Katayama, MD, PhD

Arch Dermatol. 2009;145(3):346-348. doi:10.1001/archdermatol.2008.612.

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Alexander et al¹ found that approximately 31% of 87 reported cases of melanoma in pregnancy had transplacental metastases. We describe herein a patient with stage III melanoma treated with chemotherapy.

Alexander ASamlowski WEGrossman D et al. Metastatic melanoma in pregnancy: risk of transplacental metastases in the infant. J Clin Oncol 2003;21 (11) 2179- 2186
PubMed

O'Meara ATCress RXing GDanielsen BSmith LH Malignant melanoma in pregnancy: a population-based evaluation. Cancer 2005;103 (6) 1217- 1226
PubMed

Li RHTam WHNg PCMok TSTam BLau TK Microphthalmos associated with Dartmouth combination chemotherapy in pregnancy: a case report. J Reprod Med 2007;52 (6) 575- 576
PubMed

Dipaola RSGoodin SRatzell MFlorczyk MKarp GRavikumar TS Chemotherapy for metastatic melanoma during pregnancy. Gynecol Oncol 1997;66 (3) 526- 530
PubMed

Harkin KPDrumm JEO'Brien PDaly A Metastatic malignant melanoma in pregnancy. Ir Med J 1990;83 (3) 116- 117
PubMed

Ueda EKishimoto SYasuno H Statistical survey from 1982 to 1991 of 49 patients with malignant melanocytic tumors. J Dermatol 1995;22 (7) 467- 474
PubMed

Eggermont AMSuciu SMacKie R et al. EORTC Melanoma Group, Post-surgery adjuvant therapy with intermediate doses of interferon alfa 2b versus observation in patients with stage IIb/III melanoma (EORTC 18952): randomised controlled trial. Lancet 2005;366 (9492) 1189- 1196
PubMed

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Figure 1

Clinical view of the melanoma on the thigh of a pregnant 29-year-old Japanese woman. A, Frontal view. B, Lateral view.

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Low-magnification (A) (original magnification ×100) and high-magnification (B) (original magnification ×400) hematoxylin-eosin–stained specimens taken from the melanoma on the thigh of a pregnant 29-year-old Japanese woman showed atypical cells with hyperchromasia and various sizes of nuclei in addition to mitotic figures.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Ishida I, Yamaguchi Y, Tanemura A, et al. Stage III Melanoma Treated With Chemotherapy After Surgery During the Second Trimester of Pregnancy. Arch Dermatol. 2009;145(3):346-348. doi:10.1001/archdermatol.2008.612.

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