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Correspondence |

Sweet Syndrome With Pulmonary Involvement in a Healthy Young Woman

Courtney M. Robbins, MD; Stephen E. Mason, MD; Lauren C. Hughey, MD
Arch Dermatol. 2009;145(3):344-346. doi:10.1001/archdermatol.2008.610.
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Sweet syndrome, or acute febrile neutrophilic dermatosis, is a syndrome of erythematous papules and plaques, fever, leukocytosis, and arthralgias.1,2 Although rare, Sweet syndrome can have extra cutaneous manifestations, including pulmonary, cardiovascular, renal, hepatic, ocular, and neurologic.2

Silverman  MADatner  EMJolly  BT A case presentation of Sweet's syndrome and discussion of life-threatening dermatoses. Am J Emerg Med 1996;14 (2) 165- 169
PubMed Link to Article[[XSLOpenURL/10.1016/S0735-6757(96)90125-4]]
Astudillo  LSailler  LLaunay  F  et al.  Pulmonary involvement in Sweet's syndrome: a case report and review of the literature. Int J Dermatol 2006;45 (6) 677- 680
PubMed Link to Article[[XSLOpenURL/10.1111/ijd.2006.45.issue-6]]
Garg  RSoud  YLal  RMehta  NKone  BC Myelodysplastic syndrome manifesting as Sweet's syndrome and bronchiolitis obliterative organizing pneumonia. Am J Med 2006;119 (11) e5- e7
PubMed Link to Article[[XSLOpenURL/10.1016/j.amjmed.2006.03.032]]
Peters  FPDrent  MVerhaegh  Mvan Pampus  ECSchouten  HC Myelodysplasia presenting with pulmonary manifestations associated with neutrophilic dermatosis. Ann Hematol 1998;77 (3) 135- 138
PubMed Link to Article[[XSLOpenURL/10.1007/s002770050429]]
Guia  JMFrias  JCastro  FJGracián  M Cardiovascular involvement in a boy with Sweet's syndrome. Pediatr Cardiol 1999;20 (4) 295- 297
PubMed Link to Article[[XSLOpenURL/10.1007/s002469900468]]
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Figure 1

Clinical appearance of Sweet syndrome in our patient. Diffuse bullous and ulcerated lesions appear on the lower extremities. A closer view of 1 of the violaceous pustular lesions is shown in the inset.

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Figure 2

Biopsy specimens of the skin (A) and lung (B). A, Skin biopsy specimen shows a diffuse neutrophilic dermatosis with superficial dermal edema and extravasated erythrocytes (hematoxylin-eosin, original magnification ×100). B, Lung biopsy specimen shows neutrophils within alveolar septa and spaces, macrophages, and fibrin accumulation with admixed neutrophils (hematoxylin-eosin, original magnification ×200).

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Figure 3

Chest radiograph reveals interstitial and nodular diffuse changes and a cavitary lesion in the left upper lobe.

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