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Correspondence |

Atypical Linear IgA Dermatosis Revealing Angioimmunoblastic T-Cell Lymphoma

Dany Nassar, MD; Marion Gabillot-Carré, MD; Nicolas Ortonne, MD; Karim Belhadj, MD; Laurence Allanore, MD; Jean-Claude Roujeau, MD, PhD; Martine Bagot, MD, PhD
Arch Dermatol. 2009;145(3):342-343. doi:10.1001/archdermatol.2008.607.
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Angioimmunoblastic T-cell lymphoma (AITL) is frequently accompanied by dermatologic and autoimmune manifestations. We report an unusual case of AITL associated with atypical linear IgA bullous dermatosis (LAD).

Dogan  AAttygalle  ADKyriakou  C Angioimmunoblastic T-cell lymphoma. Br J Haematol 2003;121 (5) 681- 691
PubMed Link to Article[[XSLOpenURL/10.1046/j.1365-2141.2003.04335.x]]
Martel  PLaroche  LCourville  PFrench Study Group on Cutaneous Lymphomas, Cutaneous involvement in patients with angioimmunoblastic lymphadenopathy with dysproteinemia: a clinical, immunohistological, and molecular analysis. Arch Dermatol 2000;136 (7) 881- 886
PubMed Link to Article[[XSLOpenURL/10.1001/archderm.136.7.881]]
Ortonne  NDupuis  JPlonquet  A Characterization of CXCL13+ neoplastic T cells in cutaneous lesions of angioimmunoblastic T-cell lymphoma (AITL). Am J Surg Pathol 2007;31 (7) 1068- 1076
PubMed Link to Article[[XSLOpenURL/10.1097/PAS.0b013e31802df4ef]]
Willenbrock  KBräuninger  AHansmann  ML Frequent occurrence of B-cell lymphomas in angioimmunoblastic T-cell lymphoma and proliferation of Epstein-Barr virus-infected cells in early cases. Br J Haematol 2007;138 (6) 733- 739
PubMed Link to Article[[XSLOpenURL/10.1111/bjh.2007.138.issue-6]]
Harms  MSaurat  JH Angioimmunoblastic lymphadenopathy accompanied by Duhring disease-like lesions. Hautarzt 1995;46 (11) 813
PubMed Link to Article[[XSLOpenURL/10.1007/s001050050347]]
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Figure 1

Violaceous erythema and bullae of the foot.

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Figure 2

Histopathologic (A), immunohistochemical (B), and direct immunofluorescence (C) images from the present case. A, Subepidermal blister with secondary necrotic changes of the epidermis; in the blister floor, regenerative epidermis overlays a mild dermal lymphocytic perivascular infiltrate (hematoxylin-eosin, original magnification ×100). B, Few scattered CXCL13+ lymphocytes are present within the dermal infiltrates (arrows) (original magnification ×200). C, The basement membrane zone shows a linear pattern of staining for C3 (original magnification ×200).

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