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Correspondence |

Subacute Cutaneous Lupus Erythematosus Associated With Capecitabine Monotherapy

Neil F. Fernandes, MD; Misha Rosenbach, MD; Rosalie Elenitsas, MD; Joseph M. Kist, MD
Arch Dermatol. 2009;145(3):340-341. doi:10.1001/archdermatol.2008.619.
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Subacute cutaneous lupus erythematosus (SCLE) is a variant of lupus erythematosus (LE) in which cutaneous symptoms in the form of annular, scaling plaques on sun-exposed areas are the main feature. This form of lupus is frequently seen as an adverse reaction to a variety of medications. The most commonly implicated drugs are thiazides, but SCLE may also be induced by other medications such as antifungal agents, angiotensin-converting enzyme inhibitors, statins, calcium channel blockers, and tumor necrosis factor antagonists.1 Herein we report a case of SCLE induced by monotherapy with capecitabine, a 5-fluorouracil prodrug.

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Figure 1

Erythematous, annular scaly plaques on sun-exposed areas of the V-neck chest (A) and arms (B).

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Figure 2

In a 4-mm punch biopsy specimen from the forearm, epidermal atrophy with lymphocytes is evident at the dermoepidermal junction along with vacuolar alteration and dyskeratosis. Perivascular lymphocytic infiltrate and mucinous ground substance in the dermis are also present (hematoxylin-eosin, original magnification ×100).

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