We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Correspondence |

Pityriasis Rubra Pilaris Responding Rapidly to Adalimumab

Hobart W. Walling, MD, PhD; Brian L. Swick, MD
Arch Dermatol. 2009;145(1):99-101. doi:10.1001/archdermatol.2008.527.
Text Size: A A A
Published online


Pityriasis rubra pilaris (PRP) is an uncommon papulosquamous eruption of uncertain cause. The disease is typically indolent and recalcitrant to treatment and sometimes progresses to erythroderma. Methotrexate, oral retinoids, cyclosporine, and phototherapy are traditional treatments but are limited by modest efficacy and dose-dependent adverse effects.1 The tumor necrosis factor (TNF) inhibitors infliximab and etanercept have been reported to be effective for PRP in individual case reports.2,3 Adalimumab is a fully humanized monoclonal IgG1 antibody with a high affinity and specificity for human TNF.4 This subcutaneously injected medication has shown safety and efficacy in the treatment of rheumatoid arthritis, ankylosing spondylitis, Crohn disease, psoriatic arthritis, and recently psoriasis.4 To our knowledge, we report herein the first case of PRP responding to adalimumab therapy.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Figure 1.

Pityriasis rubra pilaris demonstrating red-orange scaly plaques with characteristic islands of sparing.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Near complete resolution of the pityriasis rubra pilaris eruption after 8 weeks of adalimumab treatment (5 doses).

Graphic Jump Location




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

16 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles