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Correspondence |

Lipoatrophy Associated With Interferon Alfa Adjuvant Therapy for Melanoma

Lara Vallés, MD; Marta González, MD; Isabel Polo, MD; Ana B. Enguita, MD; Francisco Vanaclocha, MD; Pablo L. Ortiz-Romero, MD
Arch Dermatol. 2009;145(1):98-99. doi:10.1001/archdermatol.2008.531.
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Guillot  BBlazquez  LBessis  DDereure  OGuilhou  JJ A prospective study of cutaneous adverse events induced by low-dose alpha-interferon treatment for malignant melanoma. Dermatology 2004;208 (1) 49- 54
PubMed Link to Article[[XSLOpenURL/10.1159/000075046]]
Sparsa  ALoustaud-Ratti  VLiozon  EDenes  ESoria  PBouyssou-Gauthier  ML Cutaneous reactions or necrosis from interferon alpha: can interferon be reintroduced after healing? six case reports. Rev Med Interne 2000;21 (9) 756- 763
PubMed Link to Article[[XSLOpenURL/10.1016/S0248-8663(00)00221-6]]
Beiske  AGMyhr  KM Lipoatrophy: a non-reversible complication of subcutaneous interferon-beta 1a treatment of multiple sclerosis. J Neurol 2006;253 (3) 377- 378
PubMed Link to Article[[XSLOpenURL/10.1007/s00415-006-0898-0]]
Christeff  NMelchior  J-CTruchis  PPerronne  CGougeon  M-L Increased serum interferon alpha in HIV-1 associated lipodystrophy syndrome. Eur J Clin Invest 2002;32 (1) 43- 50
PubMed Link to Article[[XSLOpenURL/10.1046/j.0014-2972.2001.00940.x]]
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Figure 1.

Symmetrical depressed plaques on both thighs.

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Figure 2.

Perilobular lymphocytic infiltrate with lobular atrophy (hematoxylin-eosin, original magnification ×100).

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Figure 3.

Localized skin depression caused by lipoatrophy.

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