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Correspondence |

Exacerbation of Undiagnosed Mycosis Fungoides During Treatment With Etanercept

Philippe Lafaille, MD; Danielle Bouffard, MD; Nathalie Provost, MD
Arch Dermatol. 2009;145(1):94-95. doi:10.1001/archdermatol.2008.526.
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Etanercept, a soluble receptor antagonist to tumor necrosis factor (TNF), has been demonstrated to be effective in treating moderate to severe plaque psoriasis. It inactivates and downregulates the inflammatory and immune response induced by TNF but therefore could also reduce the host defense against malignant neoplasms.1 We report the case of a patient with preexisting undiagnosed mycosis fungoides (MF) who experienced a serious deterioration of his condition while being treated with etanercept.

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Figure 1.

Exacerbation of undiagnosed mycosis fungoides during etanercept treatment (A) and substantial clearance 3 months after discontinuation of etanercept therapy (B).

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Figure 2.

Hematoxylin phloxine saffron–stained histologic specimens showing significant epidermotropism with numerous atypical CD4+ lymphocytes compatible with mycosis fungoides (original magnification ×10 and ×40 for A and B, respectively).

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