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Progression of Undiagnosed Cutaneous T-Cell Lymphoma During Efalizumab Therapy

Claudia Hernandez, MD; Sophie M. Worobec, MD; Sujata S. Gaitonde, MD; Monika L. Kiripolsky, MD; Kristen Aquino, BS
Arch Dermatol. 2009;145(1):92-94. doi:10.1001/archdermatol.2008.530.
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Leonardi  CLToth  DCather  JC  et al.  A review of malignancies observed during efalizumab (Raptiva) clinical trials for plaque psoriasis. Dermatology 2006;213 (3) 204- 214
PubMed Link to Article[[XSLOpenURL/10.1159/000095037]]
 Raptiva [package insert].  South San Francisco, CA: Genentech; 2008
Berthelot  CCather  JMJones  DDuvic  M Atypical CD8+ cutaneous T-cell lymphoma after immunomodulatory therapy. Clin Lymphoma Myeloma 2006;6 (4) 329- 332
PubMed Link to Article[[XSLOpenURL/10.3816/CLM.2006.n.008]]
Bommakanti  SPatil  AEshoa  EChitambar  CR Efalizumab-associated lymphoproliferative disease. J Drugs Dermatol 2007;6 (6) 646- 648
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Tumors developed on the face, ears, chest, and back despite bexarotene therapy. A, Generalized erythema is visible on the chest, face, abdomen, and arms, sparing the body folds; numerous firm erythematous nodules are present on the face. B, Multiple erythematous nodules are scattered on the patient's back.

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