Porokeratosis is a rare, genetically determined disorder of epidermal keratinization characterized by lesions with keratotic borders corresponding histopathologically to compact columns of parakeratotic cells called cornoid lamellae that extend through the stratum corneum.1 The clinical variants include porokeratosis of Mibelli (PM), disseminated superficial actinic porokeratosis, linear porokeratosis, porokeratosis palmaris, plantaris et disseminate, and punctate porokeratosis.1
Clinical image revealing a whitish-red plaque on the right forearm of a 15-year-old boy. The affected area is made up of numerous whitish-red round papules that coalesce into irregular plaque and single papules, the area perimeter defined by a whitish border and cleaved by a central furrow. Slightly raised whitish-red portions can also be observed (original magnification ×20).
Dermoscopic images of the affected area exhibiting a cluster of lesions coalescing into plaque on the right forearm of a 15-year-old boy (original magnifcation of the main photograph ×10; inset, ×20). A thin whitish rim surrounds the entire perimeter of the affected area (black arrows), and brown close dots join to form a continuous line present inside the whitish rim (blue arrows). In the central portion of the lesions, a diffuse, whitish-brown pigmentation, globules, and dots (green arrows), red dots (arrowheads), and red lines (white arrows) (enlarged in the inset) can be recognized.
Histopathologic images under hematoxylin-eosin (A) and gram (B) stains (original magnification ×250 for both panels). The cornoid lamella (bright blue under gram stain) is characterized by a column of parakeratosis with a normal orthokeratotic epidermal stratum corneum above a thin granular layer. A few vacuolated and dyskeratotic cells are evident in the spinous layer.
Thank you for submitting a comment on this article. It will be reviewed by JAMA Dermatology editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 5
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.