There has always been some suspicion that a relationship exists between hormones and melanoma. First, case reports in the 1950s suggested an extremely poor prognosis for women diagnosed with melanoma during pregnancy.1,2 It was observed that melanoma rarely occurs prior to puberty,3,4 and women diagnosed with melanoma have higher survival rates than men.5,6 Estrogen receptors (ERs) and progesterone receptors were found in some melanomas.7,8 Greater tumor thickness was reported in melanomas diagnosed in pregnant women compared with nonpregnant controls.9,10
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