The patient was followed up for 3 months. She tolerated the procedure extremely well and did not experience any adverse events from the injections. She did not develop any bruising, hematomas, or increase in blisters. After 2 weeks, she reported a decrease in pain and perspiration on the right foot, which had received the BTX-A. Also, she noted a decrease in blister formation on the BTX-A–treated foot. All blisters were traced, and then the area was calculated with a digital wound measurement device (Visitrak; Smith & Nephew, Largo, Florida). The foot that received the BTX-A injections had fewer blisters than the control foot. The mean area of blister formation after therapy was 3.57 cm2 in the treated foot and 5.41 cm2 in the control foot. These values represented a 34% difference between the treated and the nontreated feet. The mean number of blisters was 6.57 in the foot treated with BTX-A and 8.42 in the control foot. Before treatment, the foot that would receive the BTX-A had 11 blisters and a total blister area of 4.6 cm2, while the control foot had 6 blisters and a total blister area of 2.6 cm2. Three weeks after treatment, a therapeutic benefit was already noticeable in the treated foot. In the control foot, however, newly formed blisters were still evident (Figure 2). At the end of 3 months, the BTX-A–treated foot had 4 blisters, with a total blister area of 1.6 cm2, while the control foot had 9 blisters, with a total blister area of 2.4 cm2. These values represented a 64% decrease in the number of blisters and a 65% reduction in blister surface area in the treated foot (Table). Most of the blisters that did develop in the BTX-A–treated foot occurred on the lateral edges and between the toes, not on the plantar aspect. This represented areas of the foot that did not receive the BTX-A injections.