Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by a generalized infection with human Betapapillomavirus species and an increased risk of squamous cell carcinomas in sun-exposed areas. In this case report, Kreuter et al describe a 37-year-old woman with primary lymphedema; depressed,
cell-mediated immunity; and persistent, generalized warts other than the EV-defining Betapapillomavirus species.
In addition, the typical histologic features of EV were missing. This combination of clinical findings was sufficiently similar to that of a 1987 report to suggest that it might be representative of a previously undescribed syndrome, distinct from EV and characterized by warts,
depressed immunity, lymphedema, and anogenital dysplasia (WILD syndrome).