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Correspondence |

Linear and Whorled Nevoid Hypermelanosis: Unique Clinical Presentations and Their Possible Association With Chromosomal Abnormality inv(9)

Seung Phil Hong, MD; Seok-Yong Ahn, MD; Won-Soo Lee, MD
Arch Dermatol. 2008;144(3):415-416. doi:10.1001/archderm.144.3.415.
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Linear and whorled nevoid hypermelanosis (LWNH) is characterized by swirls and streaks of macular hyperpigmentation along the Blaschko line and usually appears within the first 2 years of life without preceding inflammation or atrophy.1 It is occasionally associated with chromosomal abnormalities and anomalies of other organs.2

Kalter  DCGriffiths  WAAtherton  DJ Linear and whorled nevoid hypermelanosis. J Am Acad Dermatol 1988;19 (6) 1037- 1044
PubMed Link to Article[[XSLOpenURL/10.1016/S0190-9622(88)70269-8]]
Taibjee  SMBennett  DCMoss  C Abnormal pigmentation in hypomelanosis of Ito and pigmentary mosaicism: the role of pigmentary genes. Br J Dermatol 2004;151 (2) 269- 282
PubMed Link to Article[[XSLOpenURL/10.1111/bjd.2004.151.issue-2]]
Hartmann  AHofmann  UBHoehn  HBroecker  EBHamm  H Postnatal confirmation of prenatally diagnosed trisomy 20 mosaicism in a patient with linear and whorled nevoid hypermelanosis. Pediatr Dermatol 2004;21 (6) 636- 641
PubMed Link to Article[[XSLOpenURL/10.1111/pde.2004.21.issue-6]]
Choi  JCYang  JHLee  UHPark  HSChun  DK Progressive cribriform and zosteriform hyperpigmentation—the late onset linear and whorled nevoid hypermelanosis. J Eur Acad Dermatol Venereol 2005;19 (5) 638- 639
PubMed Link to Article[[XSLOpenURL/10.1111/jdv.2005.19.issue-5]]
Hsu  LYBenn  PATannenbaum  HLPerlis  TECarlson  AD Chromosomal polymorphisms of 1, 9, 16, and Y in 4 major ethnic groups: a large prenatal study. Am J Med Genet 1987;26 (1) 95- 101
PubMed Link to Article[[XSLOpenURL/10.1002/(ISSN)1096-8628]]
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Figure 1.

Multiple dark brown macular streaks displaying an inverted U shape or S shape over the anterior trunk (A) and a linear arrangement over the posterior thighs (B).

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Figure 2.

Biopsy specimen from a pigmented macule on the trunk (original magnification ×100). A, Increased melanin pigmentation in the basal layer and rete ridge elongation (hematoxylin-eosin). B, Same specimen stained with melanin (Fontana-Masson stain).

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