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Correspondence |

Clinical Improvement of Pityriasis Rubra Pilaris With Combination Etanercept and Acitretin Therapy

Kristy F. Davis, BS; Jashin J. Wu, MD; Jenny E. Murase, MD; Fredric R. Rosenberg, MD; Erik P. Sorenson, PA; Azin Meshkinpour, MD
Arch Dermatol. 2007;143(12):1589-1603. doi:10.1001/archderm.143.12.1597.
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Pityriasis rubra pilaris (PRP) is a rare chronic papulosquamous disorder of unknown cause characterized by erythematous scaly plaques, palmoplantar keratoderma, and keratotic follicular papules. The disease can be intensely painful, disabling, and difficult to treat. We report the first case of PRP treated successfully with combination etanercept and acitretin therapy.

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Figure 1.

Plaques gradually spread to cover an estimated 90% of the patient's body surface area, including his face, head, neck, shoulders, and chest.

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Figure 2.

After 7 months of combination etanercept and acitretin therapy, 85% to 90% of his plaques had resolved completely.

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