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Multiple Subcutaneous Lipomas Induced by HAART in the Absence of Protease Inhibitors

Elena Balestreire, BS; Justin M. Haught, MD; Joseph C. English III, MD
Arch Dermatol. 2007;143(12):1589-1603. doi:10.1001/archderm.143.12.1596.
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We report herein a case of atypical lipodystrophy manifesting as multiple subcutaneous lipomas in a patient with human immunodeficiency virus (HIV) undergoing highly active antiretroviral therapy (HAART) lacking a protease inhibitor.

Chen  DMisra  AGarg  A Clinical review 153: lipodystrophy in human immunodeficiency virus-infected patients. J Clin Endocrinol Metab 2002;87 (11) 4845- 4856
PubMed Link to Article[[XSLOpenURL/10.1210/jc.2002-020794]]
Riddler  SASmit  ECole  SR  et al.  Impact of HIV infection and HAART on serum lipids in men. JAMA 2003;289 (22) 2978- 2982
PubMed Link to Article[[XSLOpenURL/10.1001/jama.289.22.2978]]
Barragan  PFisac  CPodzamczer  D Switching strategies to improve lipid profile and morphologic changes. AIDS Rev 2006;8 (4) 191- 203
Wohl  DA Diagnosis and management of body morphology changes and lipid abnormalities associated with HIV infection and its therapies. Top HIV Med 2004;12 (3) 89- 93
Bornhövd  ESakrauski  AKBruhl  H  et al.  Multiple circumscribed subcutaneous lipomas associated with use of human immunodeficiency virus protease inhibitors? Br J Dermatol 2000;143 (5) 1113- 1114
PubMed Link to Article[[XSLOpenURL/10.1046/j.1365-2133.2000.03871.x]]
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Figure 1.

Multiple subcutaneous lipomas from nonnucleoside and nucleoside reverse transcriptase inhibitors.

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Figure 2.

Histopathologic section revealing a lipoma with focal spindle cell features (hematoxylin-eosin, original magnification ×10).

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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