We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
On the Horizon |

The Role of Filaggrin Mutations as an Etiologic Factor in Atopic Dermatitis

Matthew J. Zirwas, MD
Arch Dermatol. 2007;143(11):1437-1438. doi:10.1001/archderm.143.11.1437.
Text Size: A A A
Published online


Palmer  CNAIrvine  ADTerron-Kwiatkowski  A  et al.  Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006;38 (4) 441- 446
PubMed Link to Article[[XSLOpenURL/10.1038/ng1767]]
Sandilands  AO’Regan  GLiao  H  et al.  Prevalent and rare mutations in the gene encoding filaggrin cause ichthyosis vulgaris and predispose individuals to atopic dermatitis. J Invest Dermatol 2006;126 (8) 1770- 1775
PubMed Link to Article[[XSLOpenURL/10.1038/sj.jid.5700459]]
Marenholz  INickel  RRuschendorf  F  et al.  Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march. J Allergy Clin Immunol 2006;118 (4) 866- 871
PubMed Link to Article[[XSLOpenURL/10.1016/j.jaci.2006.07.026]]
Ruether  AStoll  MSchwarz  TSchreiber  SFolster-Holst  R Filaggrin loss-of-function variant contributes to atopic dermatitis risk in the population of Northern Germany. Br J Dermatol 2006;155 (5) 1093- 1094
PubMed Link to Article[[XSLOpenURL/10.1111/bjd.2006.155.issue-5]]
Weidinger  SRodriguez  EStahl  C  et al.  Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis. J Invest Dermatol 2007;127 (3) 724- 726
PubMed Link to Article[[XSLOpenURL/10.1038/sj.jid.5700630]]
Weidinger  SIllig  TBaurecht  H  et al.  Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. J Allergy Clin Immunol 2006;118 (1) 214- 219
PubMed Link to Article[[XSLOpenURL/10.1016/j.jaci.2006.05.004]]
Stemmler  SParwez  QPetrasch-Parwez  EEpplen  JTHoffjan  S Two common loss-of-function mutations within the filaggrin gene predispose for early onset of atopic dermatitis. J Invest Dermatol 2007;127 (3) 722- 724
PubMed Link to Article[[XSLOpenURL/10.1038/sj.jid.5700579]]
Barker  JNPalmer  CNZhao  Y  et al.  Null mutations in the filaggrin gene determine major susceptibility to early-onset atopic dermatitis that persists into adulthood. J Invest Dermatol 2007;127 (3) 564- 567
PubMed Link to Article[[XSLOpenURL/10.1038/sj.jid.5700587]]

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

1 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles