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On the Horizon |

The Role of Filaggrin Mutations as an Etiologic Factor in Atopic Dermatitis

Matthew J. Zirwas, MD
Arch Dermatol. 2007;143(11):1437-1438. doi:10.1001/archderm.143.11.1437.
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REFERENCES
Palmer  CNAIrvine  ADTerron-Kwiatkowski  A  et al.  Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006;38 (4) 441- 446
PubMed Link to Article[[XSLOpenURL/10.1038/ng1767]]
Sandilands  AO’Regan  GLiao  H  et al.  Prevalent and rare mutations in the gene encoding filaggrin cause ichthyosis vulgaris and predispose individuals to atopic dermatitis. J Invest Dermatol 2006;126 (8) 1770- 1775
PubMed Link to Article[[XSLOpenURL/10.1038/sj.jid.5700459]]
Marenholz  INickel  RRuschendorf  F  et al.  Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march. J Allergy Clin Immunol 2006;118 (4) 866- 871
PubMed Link to Article[[XSLOpenURL/10.1016/j.jaci.2006.07.026]]
Ruether  AStoll  MSchwarz  TSchreiber  SFolster-Holst  R Filaggrin loss-of-function variant contributes to atopic dermatitis risk in the population of Northern Germany. Br J Dermatol 2006;155 (5) 1093- 1094
PubMed Link to Article[[XSLOpenURL/10.1111/bjd.2006.155.issue-5]]
Weidinger  SRodriguez  EStahl  C  et al.  Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis. J Invest Dermatol 2007;127 (3) 724- 726
PubMed Link to Article[[XSLOpenURL/10.1038/sj.jid.5700630]]
Weidinger  SIllig  TBaurecht  H  et al.  Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. J Allergy Clin Immunol 2006;118 (1) 214- 219
PubMed Link to Article[[XSLOpenURL/10.1016/j.jaci.2006.05.004]]
Stemmler  SParwez  QPetrasch-Parwez  EEpplen  JTHoffjan  S Two common loss-of-function mutations within the filaggrin gene predispose for early onset of atopic dermatitis. J Invest Dermatol 2007;127 (3) 722- 724
PubMed Link to Article[[XSLOpenURL/10.1038/sj.jid.5700579]]
Barker  JNPalmer  CNZhao  Y  et al.  Null mutations in the filaggrin gene determine major susceptibility to early-onset atopic dermatitis that persists into adulthood. J Invest Dermatol 2007;127 (3) 564- 567
PubMed Link to Article[[XSLOpenURL/10.1038/sj.jid.5700587]]

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