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Resolution of Chronic Pain and Fingertip Ulceration Due to Hand-Arm Vibration Syndrome Following Combination Pharmacotherapy

Catherine Buell, MD; Edward Tobinick, MD; Karen Lamp, MD
Arch Dermatol. 2007;143(10):1331-1344. doi:10.1001/archderm.143.10.1343.
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Hand-arm vibration syndrome (HAVS) is a well-recognized cause of secondary Raynaud phenomenon. We report a percussionist with vibration-induced peripheral vasospasm and nonhealing fingertip ulceration that responded to combination therapy with pentoxifylline, extended-release nifedipine, and low-dose aspirin.

Herrick  AL Pathogenesis of Raynaud's phenomenon. Rheumatology (Oxford) 2005;44 (5) 587- 596
PubMed Link to Article[[XSLOpenURL/10.1093/rheumatology/keh552]]
Fridén  J Vibration damage to the hand: clinical presentation, prognosis and length and severity of vibration required. J Hand Surg(Br) 2001;26 (5) 471- 474
PubMed Link to Article[[XSLOpenURL/10.1054/jhsb.2001.0633]]
Samlaska  CPWinfield  EA Pentoxifylline. J Am Acad Dermatol 1994;30 (4) 603- 621
PubMed Link to Article[[XSLOpenURL/10.1016/S0190-9622(94)70069-9]]
Fleckenstein-Grün  G Calcium antagonism in vascular smooth muscle cells. Pflugers Arch 1996;432 (3) ((suppl)) R53- R60
Tran  HAnand  SS Oral antiplatelet therapy in cerebrovascular disease, coronary artery disease, and peripheral arterial disease. JAMA 2004;292 (15) 1867- 1874
PubMed Link to Article[[XSLOpenURL/10.1001/jama.292.15.1867]]
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Figure 1.

Left index finger before treatment.

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Figure 2.

Fingers after treatment.

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