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Paraneoplastic Raynaud Phenomenon With Digital Necrosis Associated With Hyperhomocysteinemia and Antiphospholipid Antibodies

Massimo Carducci, MD; Roberta Calcaterra, MD; Massimo Rinaldi, MD; Anna Mussi, MD; Giuditta Viola, MD; Irene Venturo, MD; Letizia Perracchio, MD; Gennaro Franco, MD; Massimo Lopez, MD; Aldo Morrone, MD
Arch Dermatol. 2007;143(10):1331-1344. doi:10.1001/archderm.143.10.1342.
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Petri  MFye  KH Digital necrosis: a paraneoplastic syndrome. J Rheumatol 1985;12 (4) 800- 802
Taillan  BCastanet  JGarnier  G  et al.  Paraneoplastic Raynaud's phenomenon. Clin Rheumatol 1993;12 (2) 281- 282
PubMed Link to Article[[XSLOpenURL/10.1007/BF02231545]]
Iamandi  CDietemann  AGrosshans  EPauli  GQuoix  E Paraneoplastic digital necrosis in a patient with small-cell lung cancer. J Clin Oncol 2002;20 (23) 4600- 4601
Chow  SFMcKenna  CH Ovarian cancer and gangrene of the digits: case report and review of the literature. Mayo Clin Proc 1996;71 (3) 253- 258
PubMed Link to Article[[XSLOpenURL/10.4065/71.3.253]]
Castro  RRiviera  IBlom  HJ Homocysteine metabolism, hyperhomocysteinemia and vascular disease: an overview. J Inherit Metab Dis 2006;29 (1) 3- 20
PubMed Link to Article[[XSLOpenURL/10.1007/s10545-006-0106-5]]
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Figure 1.

Keratinizing squamous cell carcinoma involving the perinodal tissue (hematoxylin-eosin, original magnification ×20).

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Figure 2.

Associated digital lesions. A, Distal digital gangrene of the second and third finger of the left hand. B, Necrotic lesion on the fourth toe of the left foot.

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