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Delayed Wound Healing Following Treatment With Low-Dose Interferon Alfa-2b for Cutaneous Melanoma

Alfred F. Ammoury, MD; Fouad El Sayed, MD; Jacques Bazex, MD
Arch Dermatol. 2007;143(10):1331-1344. doi:10.1001/archderm.143.10.1339.
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Adjuvant therapies for cutaneous melanoma have been well studied, and to our knowledge only high-dose interferon alfa-2b shows reproducible benefit.1 Efforts to improve the toxic effects profile of high-dose regimens have included the use of lower doses. We report a case of delayed wound healing secondary to treatment with low-dose interferon alfa-2b for cutaneous melanoma.

Tsao  HAtkins  MSober  A Management of cutaneous melanoma. N Engl J Med 2004;351 (10) 998- 1012
PubMed Link to Article[[XSLOpenURL/10.1056/NEJMra041245]]
Guillot  BBlazquez  LBessis  DDereure  OGuilhou  JJ A prospective study of cutaneous adverse events induced by low-dose alpha-interferon treatment for malignant melanoma. Dermatology 2004;208 (1) 49- 54
PubMed Link to Article[[XSLOpenURL/10.1159/000075046]]
Descamps  V Cutaneous side effects of alpha interferon. Presse Med 2005;34 (21) 1668- 1672
PubMed Link to Article[[XSLOpenURL/10.1016/S0755-4982(05)84245-9]]
Nedelec  BShen  YJGhahary  AScott  PGTredget  EE The effect of interferon alpha 2b on the expression of cytoskeletal proteins in an in vitro model wound. J Lab Clin Med 1995;126 (5) 474- 484
PubMed
Nedelec  BDodd  CMScott  PGGhahary  ATredget  EE Effect of interferon-alpha2b on guinea pig wound closure and the expression of cytoskeletal proteins in vivo. Wound Repair Regen 1998;6 (3) 202- 212
PubMed Link to Article[[XSLOpenURL/10.1046/j.1524-475X.1998.60306.x]]
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Figure 1.

Fibrin deposit covering the bottom of the wound with some areas of budding. The margins are red without signs of epidermization.

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Figure 2.

Complete wound closure 2 months after stopping interferon treatment. Note the evidence of the initial LLL-plasty.

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