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Sodium Thiosulfate as First-Line Treatment for Calciphylaxis

Felix Ackermann, MD; Annabelle Levy, MD; Eric Daugas, MD, PhD; Noel Schartz, MD, PhD; Anne Riaux, MD; Christian Derancourt, MD; Pablo Urena, MD; Celeste Lebbé, MD, PhD
Arch Dermatol. 2007;143(10):1331-1344. doi:10.1001/archderm.143.10.1336.
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The case report by Robinson et al1 concerning a woman with a renal transplant whose calciphylaxis was successfully treated with cinacalcet hydrochloride is interesting but must be interpreted with caution. We present herein our experience with a 45-year-old woman who underwent renal transplantation 10 years ago for treatment of nephropathy of undetermined origin.

Robinson  MRAugustine  JJKorman  NJ Cinacalcet for the treatment of calciphylaxis. Arch Dermatol 2007;143 (2) 152- 154
PubMed Link to Article[[XSLOpenURL/10.1001/archderm.143.2.152]]
National Kidney Foundation, K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis 2003;42 (4) ((suppl 3)) S1- S201
Weenig  RHSewell  LD Calciphylaxis: natural history, risk factor analysis, and outcome. J Am Acad Dermatol 2007;56 (4) 569- 579
PubMed Link to Article[[XSLOpenURL/10.1016/j.jaad.2006.08.065]]
Sharma  ABurkitt-Wright  ERustom  R Cinacalcet as an adjunct in the successful treatment of calciphylaxis. Br J Dermatol 2006;155 (6) 1295- 1297
PubMed Link to Article[[XSLOpenURL/10.1111/bjd.2006.155.issue-6]]
Guerra  GShah  RC Rapid resolution of calciphylaxis with intravenous sodium thiosulfate and continuous venovenous haemofiltration using low calcium replacement fluid: case report. Nephrol Dial Transplant 2005;20 (6) 1260- 1262
PubMed Link to Article[[XSLOpenURL/10.1093/ndt/gfh825]]
Baker  BLFitzgibbons  CABuescher  LS Calciphylaxis responding to sodium thiosulfate therapy. Arch Dermatol 2007;143 (2) 269- 270
PubMed Link to Article[[XSLOpenURL/10.1001/archderm.143.2.269]]
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Figure 1.

Ulcers of the right leg prior to treatment.

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Figure 2.

Healed ulcers of the right leg 4 months after treatment.

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