The greatest limitation of the DIA technology is for use on lesions that cannot be accurately represented in 2 dimensions, such as large ulcers that wrap around the curvature of the limb. In this circumstance, several standardized images of the ulcer and complex reconstruction may be necessary. However, In general, patient positioning, body curvature, or tapering of the limbs, as well as compromised accessibility can be sources of measurement error for manual tracings, and in general, DIA provides a technology that can at least partially overcome these problems. Finally, it is important to note that DIA provides information beyond the quantitative evaluation of traditional manual tracings. Because DIA involves digital photography, it provides an image and thus a basis for objective evaluation of other end points such as infection, lesion thickness, granulation status, surrounding edema, and lesion progression over time, if used at sequential time points. Overall, additional studies are needed to further assess the uses of DIA in quantitative evaluation of other cutaneous lesions and beyond.