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Correspondence |

Lymphomatoid Granulomatosis Induced by Imatinib-Treatment

Amir S. Yazdi, MD; Gisela Metzler, MD; Susanne Weyrauch, MD; Mark Berneburg, MD; Michael Bitzer, MD; Hans-Konrad Müller-Hermelink, MD; Martin Röcken, MD
Arch Dermatol. 2007;143(9):1209-1226. doi:10.1001/archderm.143.9.1222.
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Fauci  ASHaynes  BFCosta  J  et al.  Lymphomatoid granulomatosis: prospective clinical and therapeutic experience over 10 years. N Engl J Med 1982;306 (2) 68- 74
PubMed Link to Article[[XSLOpenURL/10.1056/NEJM198201143060203]]
Druker  BJSawyers  CLKantarjian  H  et al.  Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001;344 (14) 1038- 1042
PubMed Link to Article[[XSLOpenURL/10.1056/NEJM200104053441402]]
Jardin  FCourville  PLenain  P  et al.  Concomitant eosinophilia, fasciitis, and mycosis fungoides-like reaction with antinuclear autoantibodies in chronic myeloid leukaemia: role of a T-cell clone induced by imatinib. Lancet Oncol 2005;6 (9) 728- 729
PubMed Link to Article[[XSLOpenURL/10.1016/S1470-2045(05)70322-3]]
Bekkenk  MWVermeer  MHMeijer  CJ  et al.  EBV-positive cutaneous B-cell lymphoproliferative disease after imatinib mesylate. Blood 2003;102 (12) 4243
PubMed Link to Article[[XSLOpenURL/10.1182/blood-2003-07-2436]]
Seggewiss  RLore  KGreiner  E  et al.  Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood 2005;105 (6) 2473- 2479
PubMed Link to Article[[XSLOpenURL/10.1182/blood-2004-07-2527]]
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Figure 1.

Histologic images demonstrating large blastic B cells surrounding the necrosis under hematoxylin-eosin (A) (original magnification ×20) and CD20 stain (B) (original magnification ×200).

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Figure 2.

Radiologic images. A, Computed tomographic scan showing multiple large pulmonary tumors. B and C, Chest radiographs taken during imatinib therapy (B) and after discontinuation of imatinib treatment (C).

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