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Cutaneous Carcinoma During Long-term Hydroxyurea Therapy: A Report of 5 Cases

Claire Callot-Mellot, MD; Christine Bodemer, MD; Olivier Chosidow, MD; Camille Frances, MD; Zai Azgui, MD; Bruno Varet, MD; Yves de Prost, MD
Arch Dermatol. 1996;132(11):1395-1397. doi:10.1001/archderm.1996.03890350139035.
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Five cases of cutaneous carcinoma occurred during long-term hydroxyurea therapy. Herein the responsibility of this drug in the onset of the tumors will be discussed.

Report of Cases.  Five white patients with skin photo-type II or III, were living in France and had no history of cutaneous carcinoma before treatment (Table 1 and Table 2). The patients received hydroxyurea for 2 to 10 years (mean, 6½ years), with cumulative doses between 650 and 3600 g. The patients' mean age was 71 years. Cutaneous carcinomas are actually frequent in the eighth decade of life; nevertheless, we suspect hydroxyurea of having a cutaneous carcinogenic effect in these patients, although it is now impossible to prove this. Indeed, our attention was drawn because of the sudden onset of tumors over a few weeks in patient 1, the large number and size of tumors in patients 2 and 5, and the remarkable absence of


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