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Article | February 1991

Acquired Ichthyosis: A New Cutaneous Marker of Autoimmunity

Philippe Humbert, MD; Pierre Agache, MD

Arch Dermatol. 1991;127(2):263-264. doi:10.1001/archderm.1991.01680020135022.

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To the Editor.— A variety of dysimmune conditions may be seen in patients with acquired ichthyosis. Among the more common are Hodgkin's disease and sarcoidosis. Font et al¹ recently reported a new case of acquired ichthyosis in a patient with systemic lupus erythematosus. Evidence that acquired ichthyosis may be a new reported manifestation of collagenosis was supported by their case report, as well as by the observation we published 1 year ago.² Our patient was suffering from mixed connective tissue disease that may be considered as a clinical and biological form of systemic lupus erythematosus.³ Acquired ichthyosis was also reported to be associated with dermatomyositis.⁴ In a recent review of the literature, we were not able to find other cases of collagenosis related to acquired ichthyosis.⁵ The association of autoimmune conditions with acquired ichthyosis indicates that abnormal host immune response may have a role in

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Humbert P, Agache P. Acquired Ichthyosis: A New Cutaneous Marker of Autoimmunity. Arch Dermatol. 1991;127(2):263-264. doi:10.1001/archderm.1991.01680020135022.

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