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Photoallergy to Benzophenone

Elizabeth Knobler, MD; Laila Almeida, MD; Anne Marie Ruzkowski, RN; Jonathan Held, MD; Leonard Harber, MD; Vincent DeLeo, MD
Arch Dermatol. 1989;125(6):801-804. doi:10.1001/archderm.1989.01670180073009.
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• Incorrect diagnosis of photoallergy to sunscreen products represents a unique clinical dilemma. Increasing sunscreen usage for suspected idiopathic photosensitivity or a change to a sunscreen containing the same photoallergen only worsens the problem. While photoallergy to p-aminobenzoic acid and its esters is well known by dermatologists and the lay public, benzophenone photoallergy is not well appreciated. We report herein the cases of four individuals with photoallergy to oxybenzone in sunscreens. It is likely that such reactions will become more commonplace since oxybenzone is by far the most frequently used agent in modern, high sun protection factor sunscreens (>8 sun protection factor) being marketed today.

(Arch Dermatol. 1989;125:801-804)

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