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October 1988, Vol 124, No. 10 >
Article | October 1988

Duration of Minoxidil Therapy to Yield Maximum Benefit

Robert L. Rietschel, MD
Arch Dermatol. 1988;124(10):1569-1570. doi:10.1001/archderm.1988.01670100067019.
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To the Editor.—  Koperski et al,1 in a previous issue of the Archives, noted a drop in total hair counts between the 12th and 30th month of minoxidil use. This drop was seen in subjects with average and above-average response. The same protocol was employed at our study center, and the results of use to 24 months have been reported previously.2 Since long-term experience with trichogenic drugs is small, the results obtained from careful follow-up of the individuals continuing in the original protocol may provide insight as to the duration of therapy that yields maximum benefit.Our study group began with 149 subjects, but only 102 completed 12 months of study, which is a minimum amount of time for evaluating efficacy on terminal hair growth in our experience.2 While 89 individuals completed two years of the protocol, only 54 (50 men and four women) continued into their third

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