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Failure of Lysine in Frequently Recurrent Herpes Simplex Infection:  Treatment and Prophylaxis

John J. DiGiovanna, MD; Harvey Blank, MD
Arch Dermatol. 1984;120(1):48-51. doi:10.1001/archderm.1984.01650370054010.
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• Lysine has been claimed to be effective in the treatment and prevention of episodes of recurrent herpes simplex (HS) infection. We carried out a double-blind, placebo-controlled trial of oral lysine hydrochloride therapy (400 mg, three times a day) in a group of 21 patients in good general health with a history of frequently recurring infection. Using our measures of episode frequency, duration, and severity, we were unable to detect any substantial benefit of lysine therapy either as a treatment for episodes in progress or as a prophylactic drug for the prevention of recurrences. We conclude that it is unlikely that lysine improves frequently recurrent HS infections in the majority of patients.

(Arch Dermatol 1984;120:48-51)

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