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July 1976, Vol 112, No. 7 >
Article | July 1976

Acne Vulgaris:  Double-Blind Trial Comparing Tetracycline and Clindamycin

Eugenia T. Poulos, MD; Francis J. Tedesco, MD
Arch Dermatol. 1976;112(7):974-976. doi:10.1001/archderm.1976.01630310036007.
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† A double-blind prospective study was undertaken to compare low-dosage tetracycline hydrochloride and clindamycin hydrate hydrochloride in the treatment of patients with pustular acne. Clinical improvement was noted in 93.7% of those receiving tetracycline and in 92.8% of those receiving clindamycin. Of those patients who were receiving clindamycin, two patients developed diarrhea and one patient developed pseudomembranous colitis. We conclude, therefore, that clindamycin should not be used as a primary drug in the treatment of acne.

(Arch Dermatol 112:974-976, 1976)

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