We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Inhibition of Lysosomal Enzymes by Dapsone

Vincent P. Barranco, MD
Arch Dermatol. 1974;110(4):563-566. doi:10.1001/archderm.1974.01630100023005.
Text Size: A A A
Published online

The possible inhibition of lysosomal enzymes by dapsone (diaminodiphenylsulfone) was studied. Experimentally induced hypervitaminosis A in rabbits results in loss of chondroitin sulfate from cartilage matrix through the release of lysosomal enzymes.

In this study, thinning and decreased toluidine blue and Alcian blue staining of tracheal and articular cartilage produced by the administration of 500,000 international units of vitamin A daily were inhibited by the administration of dapsone. These findings strongly suggest that dapsone inhibits lysosomal enzyme activity. Inhibition of lysosomal enzyme activity may play a role in the therapeutic effects of dapsone on certain diseases such as dermatitis herpetiformis.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.