Starch granulomas result from contamination with glove powder and usually are manifested as a granulomatous peritonitis following laparotomy. There are, however, occasional reports of cutaneous reactions. Two cases of skin involvement simultaneous with peritonitis caused by starch granules and one case following removal of a wrist ganglion have been encountered. In this paper, the histologic criteria of diagnosis are described and a survey of 300 biopsies of granulomatous or persistent inflammatory lesions of the skin is made to see if cases have escaped detection. One example was discovered. Awareness of the entity is important.