Target Lesions in Granuloma Annulare

To the Editor.—  Target lesions are reported to be diagnostic of erythema multiforme.¹ This skin sign consists of a central annular erythematous portion encircled by one or more rings.

Report of a Case  A 51-year-old white woman complained of a symmetrical skin eruption on her hands, forearms, and neck seven days after receiving oxytetracycline (Terramycin) injections for pharyngitis.Target lesions appeared on the dorsum of her hands and forearms. Erythematous central papules which varied from 3 to 10 mm in diameter were each surrounded by an erythematous raised ring. In addition, numerous annular and polycyclic lesions without central involvement were distributed on the dorsum of the hands and proximal portions of the fingers, the forearms, and the neck. No vesicles or bullae were present. The palms, soles, and mucous membranes were spared.A skin biopsy specimen from the ring of a target lesion showed necrobiosis surrounded by lymphocytes, histiocytes,