We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Mast Cell Disease A Cutaneous Variant With Multisystem Involvement

Carroll F. Burgoon Jr., MD; James H. Graham, MD; David L. McCaffree, MD
Arch Dermatol. 1968;98(6):590-605. doi:10.1001/archderm.1968.01610180034004.
Text Size: A A A
Published online


Three patients are described with mast cell disease characterized by blisters superimposed on widespread skin involvement. The skin changes are present in the newborn and are invariably associated with involvement of the internal organs. The skin lesions regress slowly with age, but the visceral infiltration of mast cells may progress slowly, resembling a type of reticulosis. Skin changes may be the only expression of the disease so that complete medical evaluation is desirable.

The genetic implications of this type of disease in father and daughter are discussed.

Our three patients, and the five reported previously in the literature indicate a strong interrelationship between this type of skin involvement and mast cell infiltration of other systems. Prognosis in this variety of mast cell disease should be guarded, for two of these eight patients have died; five of the remaining six have histopathologic evidence of mast cell infiltration of the reticuloendothelial system; one of these six has gastrointestinal tract involvement and increasing numbers of mast cells in his bone marrow with spillage of mast cells into the peripheral blood.

The structural features of the mast cells were studied in three patients by histology, electron microscopy, and histochemical staining techniques. The mast cell granule contains a sulfated acid mucopolysaccharide.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.