Onychomycosis and Corneal Dystrophy. Presented by Herbert J. Spoor, MD.
A 42-year-old man has had recurrent keratitis for more than 12 years. Allergic studies correlated recurrent periods of excruciating light sensitivity and at times total vision loss with unusual mold and fungus sensitivity. Keratitis flare-ups were severe with acquisition of penicillin sensitivity. Penicillin was given for recurrent furunculosis. Results of skin tests showed a marked sensitivity to Penicillium, yeast, Candida albicans, Aspergillus, Alternaria, Hormodendrum, and extreme sensitivity to Torula. Control tests to Mucor, Cladosporium, Pullaria, Phoma, and Fusarium gave negative reactions. Reaction to a histoplasmosis culture was negative but there was marked local reaction to histoplasmin. Brucellosis culture reactions were also negative. Immunization against molds did not improve keratitis. The patient was referred for treatment of onychomycosis, May 17, 1963. Historically an epidermophytosis had been present but cultures showed only C albicans and other yeasts. The nail involvement was confined