Sensitivity tests with griseofulvin were generally speaking in agreement with published data,1 but a variation was introduced in this laboratory by testing the drug simultaneously with penicillinase in order to establish whether it would be inactivated by this enzyme. No influence was found on incorporation of penicillinase into griseofulvin-containing media.2
In order to study the mechanism of the curling factor, colonies of dermatophytes were permitted to develop on solid media (Sabouraud's dextrose agar). Small amount of griseofulvin powder were then deposited on the surface of the agar, a few millimeters distant from one side of the colony. Within a few hours, depending on the distance between the griseofulvin powder and the colony, formerly straight hyphae first became wavy, then curled, clumped together, and looked as degenerated and dejected as can be.
However, after a few days the colony revived and the fungistatic effect of griseofulvin obviously was overcome, since growth occurred not only locally, but also on top of the griseofulvin powder. We have not investigated how this inactivation of the griseofulvin occurs. This method lends itself
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
Thank you for submitting a comment on this article. It will be reviewed by JAMA Dermatology editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 6
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.