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Triamcinolone in the Treatment of Psoriasis

MAX R. GREENLEE, M.D.; WILLIAM L. EPSTEIN, M.D.
AMA Arch Derm. 1959;79(3):350-351. doi:10.1001/archderm.1959.01560150092014.
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Treatment of uncomplicated psoriasis with steroids in general is unsatisfactory.1,2 Recently, however, a new corticosteroid, triamcinolone,* has been marketed and from clinical trials appears to have a dramatic effect in relatively low doses.3-5 This remarkable observation prompted us to investigate the drug in a group of psoriatics under rigid experimental conditions.

Methods

Thirty-four patients with uncomplicated but recalcitrant psoriasis of 10 or more years' duration volunteered to be subjects.† The experimental plan called for one group to receive 4 mg. four times a day for a month; a second group, 4 mg. daily, and a third group, a placebo. All other therapy was discontinued. At the end of one month, the treatment schedule was arbitrarily changed. At random, some patients received 8 mg. daily, some a placebo, and some nothing. In the third month, all treatment was stopped and follow-up observations were made. The subjects

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