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Pancreatic Extracts in the Treatment of Psoriasis:  An Evaluation of Entozyme and Lipan

AMA Arch Derm. 1957;76(2):239-240. doi:10.1001/archderm.1957.01550200083017.
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In the past five years, there has been an increased interest in the use of pancreatic extracts in the treatment of patients with psoriasis. The advocates of pancreatic therapy have claimed improvement and remissions in as high as 77% of the patients treated.1-3

Pancreatin N. F. is a pancreatic extract containing three enzymes—amylase, lipase and trypsin— which act in the intestinal tract on carbohydrates, fats, and proteins respectively. The two products containing pancreatin which were commercially available at the beginning of this investigation were Entozyme and Lipan. In addition to containing pancreatin, Entozyme contains pepsin and bile salts, while Lipan contains vitamin Bi and vitamin D. Since the effectiveness of both Entozyme and Lipan was attributed to the action of pancreatin, these drugs were considered to be essentially the same.

The rationale for the use of pancreatin has rested on the premise


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