For some years, Dr. Charles C. Dennie has called to the attention of his students and associates a sign which he has observed to be rather pathognomonic in most cases of allergy (especially in persons with a history of eczema, hay fever and asthma). This sign is a definite wrinkle just beneath the margin of the lower lid of both eyes, which usually is present at birth or shortly thereafter. It is retained throughout life.
The accompanying photographs well illustrate this wrinkle in both a man with a history of atopic dermatitis and an 8 month old infant with eczema.
To my knowledge no one has mentioned this suggestive sign in any previous medical literature.
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