February 1946, Vol 53, No. 2 >

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Article | February 1946

TREATMENT OF SEVERE PUSTULAR DERMATOSES AND STAPHYLOCOCCIC SEPTICEMIA BY ORAL ADMINISTRATION OF PENICILLIN

EDWIN L. PFUETZE, M.D.; HAROLD G. NELSON, M.D.

Arch Derm Syphilol. 1946;53(2):128-132. doi:10.1001/archderm.1946.01510310052008.

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IN THE following pages we report 2 severe cases of pyogenic dermatitis. The first case was one of a severe pyoderma of both hands, which was treated by the oral administration of penicillin following two relapses after sulfadiazine therapy. The second case was one of extensive pustular dermatitis, involving the hands, arm and legs. This case was complicated by a hemolytic staphylococcic septicemia.

REVIEW OF EXPERIMENTAL WORK

The administration of penicillin by mouth has been ineffective due to the destruction of the antibiotic substance by the action of hydrochloric acid. This observation was made first by Abraham and Florey and their associates¹ and was subsequently verified by other investigators.² This was also proved clinically by Rammelkamp and Helm,³ who administered penicillin by mouth to 2 patients with pernicious anemia and achlorhydria. Therapeutic blood levels were obtained in these patients. More recent efforts⁴ have

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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PFUETZE EL, NELSON HG. TREATMENT OF SEVERE PUSTULAR DERMATOSES AND STAPHYLOCOCCIC SEPTICEMIA BY ORAL ADMINISTRATION OF PENICILLIN. Arch Derm Syphilol. 1946;53(2):128-132. doi:10.1001/archderm.1946.01510310052008.

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TREATMENT OF SEVERE PUSTULAR DERMATOSES AND STAPHYLOCOCCIC SEPTICEMIA BY ORAL ADMINISTRATION OF PENICILLIN

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