Acanthosis Nigricans, Juvenile Type. Presented (by invitation) by Dr. S. Rothman and Dr. A. L. Shapiro.
H. A., a girl aged 15, first noted darkening of the skin on the nape of the neck about three years ago. Since then, similar lesions have appeared on the upper part of the back, in both axillas, in the intermammary region and on the thighs and perineum.
She has been overweight and tall all her life. Her intelligence has always been above normal. Menstruation began at the age of twelve and has always been normal. The administration of thyroid had no effect on obesity or cutaneous changes.
The father (aged 47) has diabetes. The mother (aged 36) is obese but otherwise healthy. There are two normal siblings.
A physical examination revealed no organic disease except the cutaneous lesions and a "buffalo" type of obesity. The weight is 220 pounds (99.8 Kg.) and