MAPHARSEN AND NEOARSPHENAMINE ADMINISTERED BY CONTINUOUS INTRAVENOUS DRIP METHOD:  TOXICITY FOR RABBITS

As previously reported,¹ we have observed that five daily doses of neoarsphenamine varying from 0.001 to 0.008 Gm. (totaling 0.005 to 0.04 Gm.) and five daily doses of mapharsen varying from 0.0005 to 0.004 Gm. (totaling 0.0025 to 0.02 Gm.) per kilogram of body weight administered by the intravenous drip method were well tolerated by rabbits. The minimal curative doses in the treatment of acute testicular syphilis of these animals were found to be approximately 0.004 Gm. of neoarsphenamine and 0.001 Gm. of mapharsen administered once a day for five days in succession, totaling 0.02 Gm. of neoarsphenamine and 0.005 Gm. of mapharsen per kilogram of body weight.

The purpose of the present investigation was to determine the toxicity of neoarsphenamine and mapharsen administered by the intravenous drip method to normal rabbits as compared with their toxicity when given by syringe in single doses at a rate of injection