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May 1942, Vol 45, No. 5 >
Article | May 1942

CHICK EMBRYO ANTIGEN:  INTRAVENOUS USE IN DIAGNOSIS OF LYMPHOGRANULOMA VENEREUM

GEORGE E. MORRIS, M.D.; ORLANDO CAÑIZARES, M.D.
Arch Derm Syphilol. 1942;45(5):953-955. doi:10.1001/archderm.1942.01500110113013.
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The intravenous injection of human Frei antigen as a diagnostic test for lymphogranuloma venereum was introduced by Hellerstöm in 1931.1 Its value was confirmed by Gay Prieto and Egea Bueno2 and by Flandin and Turiaf.3 Ravaut, Levaditi and Maisler4 reported similar results from the use of mouse brain antigen intravenously, and Decker, Canizares and Reider,5 in a previous report from this clinic, stated that 0.1 cc. of mouse brain antigen injected intravenously produced a thermal response which could be used as an aid in diagnosis of this disease.

During the past eight months we have studied the thermal response in 24 cases of lymphogranuloma venereum and in 24 control cases after the intravenous injection of 0.1 cc. of chick embryo antigen. Thermometric readings were taken every two hours for forty-eight hours after the injection was given. Each patient also received 0.1 cc. of chick embryo

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