INTRAVENOUS DRIP METHOD IN INTENSIVE ARSENOTHERAPY OF SYPHILIS:  WITH PARTICULAR REFERENCE TO ITS APPLICATION FOR LATENT SYPHILIS AND FOR LATE STAGES OF THE DISEASE

After the observations of Hyman, Chargin, Rice and Leifer¹ on the massive dose chemotherapy of early syphilis by the intravenous drip method were published, a study was undertaken in Sing Sing Prison applying this procedure to the treatment of other than the early stages of the disease. With the encouragement and supervision at its inception by the Mount Sinai Hospital group, this investigation was begun in November 1939. Although the work is incomplete, a preliminary report is herein rendered to indicate the nature of my experience to date without any evaluation of the therapeutic efficacy of the procedure.

The syphilis clinic of Sing Sing Prison Hospital seemed admirably suited for such a study. About 350 men with syphilis are admitted to this clinic each year, the majority of whom remain under incarceration for a minimum of two years while many are confined for ten years or longer. This arrangement