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March 1939, Vol 39, No. 3 >
Article | March 1939

SULFANILAMIDE TREATMENT OF SYPHILITIC INTERSTITIAL KERATITIS:  Preliminary Report

I. Lewis Sandler, M.D.
Arch Derm Syphilol. 1939;39(3):528-529. doi:10.1001/archderm.1939.01480210143017.
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ABSTRACT

The purpose of this article is to report a case in which relapsing resistant syphilitic interstitial keratitis responded dramatically to sulfanilamide. I hesitate to report a single case but feel justified in the face of such a remarkable, rapid improvement of one of the most resistant and distressing of all syphilitic lesions. I hope that this report will stimulate further controlled studies of the use of sulfanilamide in the treatment of this condition, which may occur even while the patient is under active antisyphilitic treatment.

REPORT OF CASE  F. C. S., a white man aged 28, consulted me for interstitial keratitis which had been relapsing since he was a student in his third year of high school, at which time he also had hydrarthrosis of the left knee (Clutton's joint). Since that time at irregular intervals he had received intravenous, intramuscular and oral antisyphilitic therapy. He had had seven attacks

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