The subject of lentigo has received scant attention in the American literature, and the term has usually been employed synonymously with "ephelis" or "freckle." Freckles are due to a prenatal concentration of melanoblasts, are light brown and are usually more prominent on exposed surfaces, especially following exposure to actinic rays. Dark brown macules on covered parts of the body, differing from freckles on microscopic examination, must be considered a distinct clinical entity. Unless modern staining methods for the study of pigment activity are employed, particularly Bloch's dopa reaction, Masson's trichrome stains and the silver method, histologic changes can easily be misinterpreted, and confusion in diagnosis and classification may result. We believe that the following case of a condition which we have labeled "generalized lentigo" presents sufficient features of interest to warrant a detailed report.
REPORT OF A CASE
History.—Miss V. M., aged 24, from Moberly, Mo., was first